It would be good to have a custom Release or Patch Process. Patches should be installed in a specific order with delay between instances of some weeks.
Patch Order: (DEV Instance --> Quality-Instance --> PROD).
But in a production, it could be very critical. A Patch was crashing our application. This apoc was not more working after the patch: Apoc.periodic.iterate is throwing null pointer exception in AURA DB with Neo4j 5.18.0
(see Ticket 00030116)